Ayon sa ICD-10 (International Statistical Classification of Diseases and Related Health Problems), ang Down syndrome ay inuri bilang mga sumusunod, depende sa pinaghihinalaang etiology (sanhi):
- ICD-10 Q90.0: Trisomy 21, meiotic nondisjunction (Libreng trisomy 21).
- ICD-10 Q90.1: Trisomy 21, mosaic (mitotic non-disjunction).
- ICD-10: Q90.2 trisomy 21, paglipat
- ICD-10: Q90.9 Down Syndrome, hindi natukoy.
